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To extend our investigation, we employed the hydrodynamic tail-vein injection (HDTVi) model with spontaneous HCC tumors induced by CRISPR/Cas9-mediated loss-of-function genome editing of endogenous TP53 and Sleeping Beauty (SB) transposon-driven c-Myc overexpression in C57BL/6 mice [16] (Additional file 1: Fig

These findings suggest it could be of interest in research aimed at reducing the necessary doses of radiation in the treatment of certain types of cancer, reducing side effects and the occurrence of secondary tumors appearing during treatment

Conclusions and perspectives Various cellular metabolic activities, including redox balance, iron transport and metabolism, mitochondrial function, and the processing of lipids and amino acids, along with diverse disease-related signaling pathways, regulate ferroptosis

31 Mogensen KM, Robinson MK

Beyond their roles in redox chemistry and protein stabilization, thiols are involved in cellular signaling pathways, enzymatic catalysis, and metal ion homeostasis