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The authors will also present their thoughts on a proposed multimodal perioperative protocol focused on identifying limb edema/lymphedema preoperatively, intraoperative technique changes that may decrease swelling, and lastly mitigating acute post-operative swelling response with the intent of decreasing pain, improving patient outcomes, and reducing the morbidity of chronic post-operative edema

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Dose adaption or even a change of medication might be indicated in smokers with BD, i.e., for olanzapine and clozapine a 50% higher dosage might be required (65)

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