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In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity

If these illness-associated behaviors persist, they can lead to the development of psychological distress, such as clinical depression and anxiety

J Biol Chem 274:1849218502

Nowadays, this is used as a Music Centre, and an exhibition space

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