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Intriguingly, the protein level of ARR2 was significantly lower in the brain of Sorl1 -deficient mice compared to control mice (Fig

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In 2025, the FDA approved elamipretide, manufactured by Stealth BioTherapeutics, to improve muscle strength in patients with Barth syndrome [4]

2.2 Gene mutations and drug target alterations The development of drug resistance in Mtb is predominantly driven by genetic mutations that alter drug targets or drug activation pathways, reducing the efficacy of anti-tubercular agents