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Aspirin Depletes Vitamin C In the 1970s, researchers noticed that people with chronic diseases (notably, rheumatoid arthritis) who took aspirin daily for pain relief had an increased susceptibility to infections

Neuroendocrinology 51, 9396

Splenocytes from -MYC mice and wild-type littermates were isolated as previously described [53] and stained with APC-conjugated rat anti-mouse CD45R/B220 (ref 561880) and PE-conjugated rat anti-mouse CD43 (ref 561857) antibodies, both from BD Biosciences, before flow cytometry analysis with a FACS Canto II flow cytometer (BD Biosciences) employing Kaluza software (Beckman Coulter)

The fact that copper is an inhibitor of the CBS enzyme that leads to glutathione synthesis (101) and vitamin B6 is a cofactor for four enzymes related to this pathway, may explain why vitamin B6 is underutilized in the setting of high free copper and why HCY is also elevated in this setting

We aimed to identify novel MTB antigens and assess their protective efficacy as TB vaccine candidates