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Abstract Estrogen-related receptors (ERR//) are ligand-responsive nuclear receptors that coordinate oxidative metabolism, mitochondrial biogenesis, and substrate selection in energetically active tissues

Building on genetic and omics studies that have been completed thus far, in combination with multi-omics approaches, which allow for both temporal and spatial deconvolution of gene, protein, and other biomolecule expression at unprecedented resolution, we are well on our way to building a comprehensive profile of many aspects of the IVD

Besides the genetic factors, environmental factors such as diet, lifestyle, obesity, and chronic stress are involved in migraine pathogenesis (710)