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Studies have demonstrated that HIF-1 can reduce DNA damage in cancer cells through an unknown mechanism, further contributing to the drug resistance of several cancer types, including triple-negative breast cancer (TNBC) and prostate cancer (PC) (172)

To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain

Arch Gen Psychiatry 2004

Glutathione protects the mitochondria that generate this energy, helping your body stay alert during the day and recover fully at night

7m, o), an effect that was absent for clemastine (Fig