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Interestingly, Se deficiency is associated with pro-longevity mechanisms because of reduced amino acid levels and altered nutrient signaling

It plays a central role in: Detoxifying toxins and heavy metals Supporting immune health and inflammation balance Regenerating other antioxidants (like vitamins C and E) Maintaining mitochondrial energy production Slowing the cellular aging process A low Glutathione Index may reflect oxidative stress or a depletion of antioxidant capacity

Typically, MT is found in the cytoplasm, but it can also translocate into the nucleus to safeguard DNA from damage and interact with transcription factors, which will be further elaborated on later

Molecules 27:5481

Depleting the dopamine level in PD will lead to overactivity of the indirect pathway and under activity of the direct pathway within the basal ganglia circuitry (41)