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407 The PI3K/Akt pathway is crucial in sensing nutrients and regulating cellular metabolism, controlling cellular functions such as growth, survival, and metabolism

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Moreover, AMPK and mTORC1 play opposing roles in controlling cellular metabolism, and the activity of mTORC1 is suppressed by AMPK through a dual mechanism involving the phosphorylation-induced activation of tuberous sclerosis complex 2 (TSC2) 162 and the phosphorylation-mediated inhibition of regulatory-associated protein of mTOR (Raptor), a component of the mTORC1 complex

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