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Gastrointestinal adverse events, mostly mild or moderate, were more frequent in the treatment group (72.5%) than in the placebo group (34.4%)

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REDEFINE-1: adults with obesity, no diabetes Design: 3,417 adults with BMI 30 (or 27 with a comorbidity), without type 2 diabetes, for 68 weeks

Unlike prior meta-analyses predominantly focused on MCI and dementia, this review emphasizes feasibility, usability, and the integration of cognitive and physical tasks within VR interventions, offering new clinical insights relevant for early-stage intervention

Deep learning on MRI affirms the prominence of the hippocampal formation in Alzheimer's disease classification