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2 The high rate of drug and toxin delivery to the kidney, due to its high renal blood flow (accounting for about 25% of cardiac output), exposes the kidney to elevated concentrations of these substances, which can lead to nephrotoxicity

Muscle cells respond by producing more mitochondria and more mitochondrial enzymes

Sharabi et al., 2003

The circadian rhythm of TNF was significantly altered in sleep apnea patients the peak concentrations that occurred during the night in normal control subjects were not present in sleep apnea patients