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Indeed, hydrochlorothiazide gained widespread popularity following a controlled trial for the management of hypertension published in 1970 (Collins et al., 1990

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MAPK participates in the intracellular signaling to: (1) induce the gene expression of redox sensitive transcription factors, such as activator protein-1 (AP-1) and nuclear factor B (NF-B) (Pinkus et al., 1996), (2) stimulate apoptosis (Clement and Pervaiz, 1999), and (3) modulate cell proliferation (Lundberg et al., 2000)

56 These results highlight the possibility that genetic variation may have significant effects on susceptibility toward cancer