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1 Introduction Osteosarcoma (OS), a highly aggressive malignancy predominantly affecting adolescents, continues to pose significant clinical challenges due to its elevated mortality rate and propensity for recurrence and metastasis despite advancements in multimodal therapies ( Emerging as a distinct form of regulated cell death, ferroptosis diverges fundamentally from apoptosis in its biochemical execution ( + /Fe + -mediated Fenton reactions that catalyze hydrogen peroxide (H 2 O 2 ) decomposition ( Against this backdrop, Rhizoma Paridis, a traditional Chinese medicinal herb, and its major bioactive components, Rhizoma Paridis total saponins (RPTS), have attracted attention for their potent antitumor activities

Finally, the main issues for future revisions are presented as Future Research Questions

Sun at the Institute of Physics, CAS, for their invaluable assistance in cryo-EM data collection

165,166 Upon mTORC1 activation, LARP1 is phosphorylated, relieving this repression 167,168 and facilitating the translation of TOP mRNAs via interaction with RAPTOR

RESEARCH USE ONLY These materials are strictly intended for laboratory research and in vitro testing only