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The ability of benfotiamine to inhibit three major pathways (the hexosamine pathway, the AGE formation pathway, and the diacylglycerol (DAG)-PKC pathway) simultaneously might be clinically useful in preventing the development and progression of diabetic complications

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B-Complex: A group of vitamins that helps support healthy skin, hair, and nails, while also boosting energy and mood

Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy

[11] This reinforces that NAD+ therapy, when administered in a controlled medical setting, has a favorable safety profile